Endocrine Abstracts

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...

Objective: Remission of Cushing’s disease (CD) in the postoperative vary between 55–85%, recurrence of up to 25%. Remission and recurrence rates vary dependent on tumor size and neurosurgical expertise. The objective of this study is to describe whether there are clinical data that help us to predece recurrence of CD after transsphenoidal surgery (TSS).Patients and Methods: Retrospective analysis of patients who underwent as TSS for CD. Varia...

Background: Germ cell tumors (germinoma, teratoma, embryonal carcinoma, yolk sac tumor and choriocarcinoma) constitute 0.3–3.4% of all primary intracraneal tumors. Germinoma is the most common and of better prognosis.Aim: Describing the behaviour of germ cell tumors of the pituitary–hypothalamic region: location, clinical characteristics, diagnosis and follow-up.Material and methods: Review of medical records of patients ...

Most kindreds of familial isolated pituitary adenomas (FIPA) with mutated AIP develop somatotropinomas, characterized by an aggressive clinical phenotype including early age at diagnosis, large tumours and frequent invasiveness. In non-family cases, the prevalence of AIP mutations in pituitary adenomas is lower than 10%. There is no information of AIP prevalence in isolated somatotropinomas characterized by poor response to conventional treatment.Aim: To...

Women suffering gestational diabetes mellitus (GDM) are a risk group for type 2 diabetes. The genetic determinants are not widely known and controversial data exists about association between K121Q PC-1 gene polymorphism and early type 2 diabetes and/or IR.The aim of the study was to investigate the relationship between K121Q PC- 1 gene polymorphism and the glucose metabolic alterations, IR or metabolic syndrome in GDM women in the postpartum period....

Introduction: Pituitary abscess (PA) is a rare condition, representing less than 1% of pituitary lessions. Only around 200 cases have been reported in the scientific literature. Preoperative diagnosis is often challenging due to nonspecific clinical and radiological manifestations.Materials and methods: Retrospective descriptive cohort study. We analyze demographic and clinical variables, hormonal involvement, recurrence, type of surgery and antibiotic t...

Methods: Descriptive retrospective study among patients who underwent ETPS for ACTH-secreting pituitary adenomas performed by the same surgical team from January/2013 to January/2017.Results: 27 ACTH-secreting pituitary adenomas operated via ETPS. 20 (74.1%) were women, median age at surgery was 43.25 [29.65–61.59] years and median follow-up was 3.13 [1.6–6.69] years. Presurgically, 25 (92.59%) patients recieved drugs for control cortisol hyper...

Methods: We conducted a retrospective descriptive study including 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS beetwen January/2013 to January/2017.Results: Among 67 patients with non-functioning pituitary adenomas surgicaly removed via ETPS 44 (65.67%) were men. 52 (77.61%) patients recieved their first surgery, 14 (20.9%) had been operated one time before and 1 (1.49%) had been operated two times. Every patient reopera...

Introduction: Thyroid cancer is the most frequent malignant endocrine neoplasia. Its incidence has significantly risen worldwide in the last decades.Objective: To estimate the incidence of thyroid cancer in Valladolid’s east area population, Spain, over the period 2002–2016.Methods: A retrospective descriptive research was performed in the Clinical Universitary Hospital of Valladolid (HCUVa). Clinical data was obtained fr...

Objective: This study aims to assess the utility of salivary cortisol (SC) in diagnosing adrenal insufficiency (AI) and to analyze the integrity of the hypothalamic-pituitary-adrenal axis. This involves evaluating cortisol rhythm, its correlation with plasma levels, and the impact of exogenous hydrocortisone (HC) substitution on SC determination.Methods: A prospective study was conducted on all patients with suspected AI undergoing adrenocorticotropic ho...